How to Use de novo in a Sentence

de novo

adverb or adjective
  • The last de novo to open in the Houston area was Mint National Bank.
    Andrea Leinfelder, Houston Chronicle, 30 Sep. 2019
  • Couch asked for a trial de novo, which is a new trial on the entire case.
    Ko Lyn Cheang, The Indianapolis Star, 5 Apr. 2023
  • Instead, by applying de novo, the NFL had a lower bar to meet.
    Michael McCann, SI.com, 12 Oct. 2017
  • In fact, with every decade of life, the number of de novo mutations in sperm doubles.
    Alice Park, Time, 23 Dec. 2019
  • Greg really was a large part of the reason why Goat was created, but this was his first de novo deal, was Ring.
    Recode Staff, Recode, 20 Apr. 2018
  • The study from the other team is in press, but found neither inherited nor de novo variants linked to autism in the regions.
    Nicholette Zeliadt, Scientific American, 19 Apr. 2018
  • Point two: The reality is that Trump, on this as on everything else, is not de novo.
    David Roberts, Vox, 3 Dec. 2018
  • Known as de novo, it can be used to bring novel, low-risk medical devices to market.
    Rachana Pradhan, CNN, 26 Nov. 2021
  • Most of these genes lead to autism primarily through de novo variants — variants that are new in the person and not present in their parents.
    Pamela Feliciano, STAT, 22 Aug. 2022
  • Rivers was diagnosed de novo, which meant the breast cancer had already spread to other parts of her body at the time of diagnosis.
    Sierra Leone Starks, Allure, 9 Dec. 2022
  • If not, what are these giants doing to make that de novo certificate meaningful at the top of the hiring funnel?
    Ryan Craig, Forbes, 11 June 2021
  • Without the freedom of de novo protein design, Baker’s Death Star would never have gotten off the ground.
    Jonathon Keats, Discover Magazine, 30 Oct. 2018
  • Rosetta contained a precise model of the spike; Cao had written scripts that used that model to generate, de novo, binders that might work.
    Matthew Hutson, The New Yorker, 18 Sep. 2020
  • Yet, in a strict sense, nothing in evolution is created de novo.
    Quanta Magazine, 9 Apr. 2020
  • The next step is to better understand how de novo mutations function over time.
    Alice Park, Time, 23 Dec. 2019
  • That confirmed that the de novo mutations were indeed playing some role in contributing to autism.
    Alice Park, Time, 23 Dec. 2019
  • Some early efforts to use deep learning for de novo protein design have not made use of large language models.
    Rob Toews, Forbes, 16 July 2023
  • When taking up an appeal of a close DRB vote, one where only three of the five-member panel supported the decision in question, the council will review the case de novo.
    Daily Pilot, 7 Aug. 2019
  • That is, the whistleblower must show that the IRS in its decision on the facts was arbitrary and capricious (as opposed to the more traditional de novo review – where the court decides the issue).
    Dean Zerbe, Forbes, 17 Aug. 2022
  • The girls’ specific gene mutation — known as de novo SPG4 — is extremely rare.
    Dana Hedgpeth, Washington Post, 19 Mar. 2023
  • Many of them may also be de novo, and part of the reason why paternal age is so important in predicting these tendencies in offspring.
    Razib Khan, Discover Magazine, 24 Jan. 2013
  • While many FIs see de novo and challenger banks as a threat, traditional banks have something that these new players often really need: a charter.
    Jeffery Kendall, Forbes, 28 May 2021
  • What that does is provides more sequence diversity and eliminates bias in de novo designs.
    John Cumbers, Forbes, 10 Jan. 2023
  • The company says the results are significant and under review by the FDA for possible de novo pre-market approval.
    Stat Staff, STAT, 20 Sep. 2021
  • But some scientists say that de novo protein design will lead to medicines that can’t be made from optimizing existing proteins.
    Ryan Cross, BostonGlobe.com, 3 Nov. 2022
  • For Baker, de novo design represents the summit of his quarter-century quest.
    Jonathon Keats, Discover Magazine, 30 Oct. 2018
  • Sometimes this means applying for a de novo license, sometimes this is an acquisition.
    Steven Ehrlich, Forbes, 30 Aug. 2021
  • Protein researchers and entrepreneurs seem even more excited about AlphaFold’s potential to boost the burgeoning field of de novo protein design.
    Rob Toews, Forbes, 3 Oct. 2021
  • At this moment, the helpful types of de novo proteins are attracting an increasing amount of scientific energy and expertise, and the molecules may be coming to a clinic near you.
    Rowan Jacobsen, Scientific American, 27 June 2021
  • Later, at a big hospital in Columbus, an oncologist diagnosed me with metastatic breast cancer de novo.
    Tori Geib As Told To Zee Krstic, Good Housekeeping, 16 Dec. 2020

Some of these examples are programmatically compiled from various online sources to illustrate current usage of the word 'de novo.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback about these examples.

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